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KMID : 0616120070380030277
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.277 ~ p.280
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Inhibitory Activity of Ethanol Extracts of Ailanthus altissima and Luteolin-7-glucoside on Phospholipase A2 activity
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Jin Mei-Hua
Chang Hyun-Wook
Bae Ki-Hwan
Son Kun-Ho
Yang Ju-Hye
Kim Hyun-Pyo
Kang Sam-Sik
Hong Tae-Gyun
Hwang Nam-Kyung
Chung Hwan-Ki
Kim Yun-Kyung
Zhejiu Quan
Pham Ngoc Thanh
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Abstract
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In our continuing effort to investigate compounds having anti-inflammatory activity from natural products, Ailanthus
altissima was examined. Among six compounds isolated from Ailanthus altissima, Luteolin-7-O-glucoside (L7G) along with ethanol extract of Ailnathus altissima (EAa) were chosen to determine their inhibitory activity on secretory recombinant phospholipase A2s enzyme activity in vitro. As a results, EAa inhibited human recombinant sPLA2-V (IC50 of about 100 μg/ ml) and cPLA2, (IC50 of about 59 μg/ml), while L7G showed strong inhibitory effect on sPLA2-A, V and cPLA2 with an IC50 value of approximately 40 μM, respectively.
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KEYWORD
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Ailanthus altissima, Luteolin-7-O-glucoside, Phospholipase A2, inflammation
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